Leinco Technologies

Anti-Mouse CD172a - APC

Product Code:
 
LEI-P389
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
P84
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
2-8°C
Storage:
 
This Allophyc°Cyanin (APC) conjugate is stable when stored at 2-8°C. Do not freeze.
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LEI-P389-50ug50 ug£205.00
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LEI-P389-100ug100 ug£338.00
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Further Information

Antigen Distribution:
CD172a is expressed on monocytes, macrophages, dendritic cells, and neuronal cells.
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
Allophycocyanin (APC)
Format:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
Mouse brain membrane protein
Long Description:
CD172a antibody, clone P84, recognizes CD172a, also known as single regulatory protein α (SIRPα) (signal regulatory protein alpha) or Src homology 2 domain-containing phosphatase substrate-1 (SHP-1), a type I transmembrane glycoprotein with three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs)1. SIRPα is expressed predominantly in myeloid cells2 - including monocytes, macrophages, and dendritic cells (DCs) - and neuronal cells3. The extracellular ligand for SIRPα, CD47 (or integrin-associated protein [IAP])4, is expressed in most cell types5. In macrophages, ligation of SIRPα by CD47 inhibits macrophage phagocytosis of self cells6,7. SIRPα also negatively regulates DC-mediated T cell activation and DC maturation8-10. CD47 is also upregulated on tumor cells, inhibiting the phagocytosis of tumor cells by macrophages11. Therapeutics targeting the CD47-SIRPα interaction, including antibodies and fusion proteins, are currently under preclinical and clinical study for various malignancies as a monotherapy or in combination with other therapeutics12.
NCBI Gene:
16421
Target:
CD172a

References

1. Fujioka, Y., et al. (1996) Mol. Cell. Biol. 16:6887 2. Adams, S., et al. (1998) J. Immunol. 161:1853 3. Chuang W, et al. (1990) Dev Biol. 137:219?232 4. Seiffert, M., et al. (1999) Blood 94:3633 5. Oldenborg P. A. (2013) ISRN Hematol. 2013:614619 6. Oldenborg, P. A., et al. (2000) Science 288:2051 7. Oldenborg, P. A., et al. (2001) J. Exp. Med. 193:855 8. Brooke, G. P., et al. (1998) Eur. J. Immunol. 28:1 9. Seiffert, M., et al. (2001) Blood 97:2741 10. Latour, S., et al. (2001) J. Immunol. 167:2547 11. Jaiswal S, et al. (2009) Cell. 138(2):271-85 12. Jalil AR, et al. (2020) Antib Ther. 3(2):80-94