MBL

Anti-TLR4-MD-2 complex (Mouse) mAb

Product Code:
 
MBL-D079-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
MTS510
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Immunoprecipitation (IP)
Shipping:
 
4°C
Storage:
 
-20°C
1 / 2
2 / 2
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MBL-D079-3100 ug£323.00
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Further Information

Applications:
IP - It is reported that clone MTS510 can be used in this application FCM - 10-20 ug/mL NT - It is reported that clone MTS510 can be used in this application
Background:
TLR4 (Toll-like receptor 4), a member of Toll-like receptor family, may act as a receptor for LPS (lipopolysaccharide). It associates with the MD-2 molecule by its extracellular domain. The LPS signal through TLR4 may be greatly enhanced by this association. This antibody (clone MTS510) reacts selectively with mouse TLR4-MD-2 complex but not with TLR4 alone in flow cytometry.
Concentration:
1 mg/ml
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol. No preservative iscontained.
Gene IDs:
Human: 7099 Mouse: 21898
Immunogen Translated:
Ba/F3 cells expressing mouse TLR4-MD-2 complex
Reactivity:
This antibody reacts with mouse TLR4-MD-2 complex on Flow cytometry. This antibody doesn?t react with mouse TLR4 alone.
Shelf Life:
1 year
Source:
This antibody was purified from culture supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with Wister rat lymph node cells immunized with mouse Ba/F3 cells expressing mouse TLR4-MD-2 complex.
Target:
TLR4-MD2

Documents

References

1) Wakabayashi, Y., et al., J. Immunol. 177, 1772-1779 (2006) 2) Kobayashi, M., et al., J. Immunol. 176, 6211-6218 (2006) 3) Akashi-Takamura, S., et al., J. Immunol. 176, 4244-4251 (2006) 4) Saitoh, S., et al., Int. Immunol. 16, 961-969 (2004) 5) Akashi, S., et al., J. Exp. Med. 198, 1035-1042 (2003) 6) Yazawa, N., et al., Blood 102, 1374-1380 (2003) 7) Kawasaki, K., et al., J. Immunol. 170, 413-420 (2003) 8) Nagai, Y., et al., Nat. Immunol. 3, 667-672 (2002) 9) Akashi, S., et al., Int. Immunol. 13, 1595-1599 (2001) 10) Ogata, H., et al., J. Exp. Med. 192, 23-30 (2000) 11) Nomura, F., et al., J. Immunol. 164, 3476-3479 (2000) 12) Akashi, S., et al., J. Immunol. 164, 3471-3475 (2000) 13) Akashi, S., et al., Biochem. Biophys. Res. Commun. 268, 172-177 (2000) 14) Shimazu, R., et al., J. Exp. Med. 189, 1777-1782 (1999) Clone MST510 is used in reference number 1) - 12).