MBL

Anti-CD28 (Mouse) mAb Functional Grade

Product Code:
 
MBL-FP20372510
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Hamster
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
37.51
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Flow Cytometry
  • Functional Study
  • Immunoprecipitation (IP)
Shipping:
 
4°C
Storage:
 
4°C
 

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MBL-FP20372510100 ug£312.00
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  • Further Information
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Further Information

Background:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.
Concentration:
2 mg/mL
Formulation:
Phosphate-buffered aqueous solution, ph7.2.
Target:
CD28

Documents

References

Sanchez-Madrid, F., et al., J Exp Med. 158, 586-602 (1983) Ault, K. A., & Springer, T. A., J Immunol. 126, 359-364 (1981) Springer, T., et al., Eur J Immunol. 8, 539-551 (1978)