Elabscience

Recombinant Rhesus Macaque SLAM Family Member 7/SLAMF7/CD319/CRACC (C-6His)

Product Code:
 
PKSQ050108
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Monkey
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
 

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CodeSizePrice
PKSQ050108-10ug10ug£183.00
Quantity:
PKSQ050108-50ug50ug£392.00
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This product comes from: China.
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Further Information

Abbreviation:
SLAMF7;CD319;CRACC
Accession:
F7HQ72
Background:
SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
Calculated MW:
23.3 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
30-50 kDa
Purity:
> 95 % as determined by reducing SDS-PAGE.
Sequence:
Ser23-Met226
Target Synonym:
SLAM Family Member 7;CD2 Subset 1;CD2-Like Receptor-Activating Cytotoxic Cells;CRACC;Membrane Protein FOAP-12;Novel Ly9;Protein 19A;CD319;SLAMF7;CS1
UNIProt ID:
F7HQ72

Documents