Recombinant Mouse CD39/ENTPD1 Protein (His Tag)

CD39;ENTPD1

P55772

Ectonucleoside triphosphate diphosphohydrolase-1(NTPDase-1)is an integral membrane protein with an extracellular active site. Recombinant mouse NTPDase-1wasexpressed as a protein lacking its N- andC-terminaltransmembrane domains, resulting in the secretion of the soluble ectodomain. NTPDase-1was originally describedas CD39, a B lymphocyte cell surface marker. but it is also present on the surface of natural killer cells, T cells, and some endothelial cells. NTPDase1hydrolyzes the β-andγ phosphate residues of nucleotides, preferring ATP as the substrate. Through its hydrolysis of extracellular nucleotides, NTPDase-1plays arole in the regulation of purinergic signaling. NTPDase-1is involved in the processes of thromboregulation and vascular inflammation. The administration ofsoluble NTPDase-1may have therapeutic applications for the treatment of some vascular and transplantation-associateddiseases.

50.5 kDa

< 1.0 EU per ug of the protein as determined by the LAL method.

HEK293 Cells

Supplied as a 0.2 um filtered solution of 20mM Tris,500mM NaCl,10% Glycerol,pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

C-His

60-90 kDa

> 95 % as determined by reducing SDS-PAGE.

Thr38-Ile478

Ectonucleoside triphosphate diphosphohydrolase 1;NTPDase 1;NTPDase 1;Ecto-ATP diphosphohydrolase 1;Ecto-ATPDase 1;Ecto-ATPase 1;Ecto-apyrase;Lymphoid cell activation antigen;CD39

P55772