Elabscience

Recombinant Human Cathepsin S/CTSS Protein (His Tag)(Active)

Product Code:
 
PKSH033736
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt store it immediately at < -20°C.
Storage:
 
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
 

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CodeSizePrice
PKSH033736-10ug10ug£288.00
Quantity:
PKSH033736-50ug50ug£436.00
Quantity:
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Further Information

Abbreviation:
Cathepsin S;CTSS
Accession:
P25774
Activity:
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2 The specific activity is 9063. 642 pmol/min/ug.
Background:
Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer?s disease(AD) and Down Syndrome (DS).
Calculated MW:
36.9&25&11.2 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Supplied as a 0.2 um filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
37-40&26-28&14-16 kDa
Purity:
> 90 % as determined by reducing SDS-PAGE.
Sequence:
Gln17-Ile331(pro)&Ser109-Ile331&Gln17-Ser109(Propeptide)
Target Synonym:
Cathepsin S;CTSS;CTSS;MGC3886
UNIProt ID:
P25774

Documents