Elabscience

APC Anti-Mouse CD115 Antibody[AFS98]

Product Code:
 
E-AB-F1107UE
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rat
Antibody Isotype:
 
Rat IgG2a, κ
Antibody Clone:
 
AFS98
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
Ice packs
Storage:
 
Store at 2-8°C and protected from prolonged exposure to light. Do not freeze.
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C57BL/6 murine abdominal macrophages elicited by starch broth are stained with FITC Anti-Mouse CD11b Antibody and APC Anti-Mouse CD115 Antibody (Left). Abdominal macrophages are stained with FITC Anti-Mouse CD11b Antibody and APC Rat IgG2a, κ Isotype Control (Right).
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C57BL/6 murine abdominal macrophages elicited by starch broth are stained with FITC Anti-Mouse CD11b Antibody and APC Anti-Mouse CD115 Antibody (Left). Abdominal macrophages are stained with FITC Anti-Mouse CD11b Antibody and APC Rat IgG2a, κ Isotype Control (Right).

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CodeSizePrice
E-AB-F1107UE-25ug25ug£133.00
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E-AB-F1107UE-100ug100ug£229.00
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Further Information

Abbreviation:
CD115/CSF-1R
Background:
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Concentration:
0.2 mg/mL
Conjugation:
APC
GeneID:
12978
Target Synonym:
Macrophage colony-stimulating factor 1 receptor;CSF-1 receptor (EC:2.7.10.1);CSF-1-R;CSF-1R;M-CSF-R;Proto-oncogene c-Fms;CD115;Csf1r;Csfmr;Fms;
UNIProt ID:
P09581
Usage:
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 ug/10^6 cells in 100 uL volume].

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