Elabscience

Recombinant Human Caspase-10/CASP10 Protein (His Tag)

Product Code:
 
PKSH032176
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
The product is shipped on dry ice/blue ice. Upon receipt store it immediately at the storage temperature listed.
Storage:
 
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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CodeSizePrice
PKSH032176-10ug10ug£536.00
Quantity:
PKSH032176-50ug50ug£833.00
Quantity:
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Further Information

Abbreviation:
Caspase-10;CASP10
Accession:
Q92851-2
Background:
Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). CASP10 cleaves and activates caspases 3 and 7, but itself is processed by caspase 8. Defects in CASP10 are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.
Calculated MW:
30.1 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Supplied as a 0.2 um filtered solution of 25mM HEPES, 10mM DTT, pH 7.5.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-6His
ObservedMW:
33 kDa
Purity:
> 90 % as determined by reducing SDS-PAGE.
Sequence:
Val220-Ile480
Target Synonym:
Caspase-10;CASP-10;Apoptotic Protease Mch-4;FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2;FLICE2;ICE-Like Apoptotic Protease 4;CASP10;MCH4
UNIProt ID:
Q92851

Documents