Elabscience

EGFR Monoclonal Antibody

Product Code:
 
E-AB-22075
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Mouse
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Clone:5F3
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
-20°C
1 / 1
Western Blot analysis of 1) A431, 2) Hela cells using EGFR Monoclonal Antibody at dilution of 1:2000.
❮❯

Western Blot analysis of 1) A431, 2) Hela cells using EGFR Monoclonal Antibody at dilution of 1:2000.

No additional charges, what you see is what you pay! *

CodeSizePrice
E-AB-22075-20uL20uL£125.00
Quantity:
E-AB-22075-60uL60uL£172.00
Quantity:
E-AB-22075-120uL120uL£237.00
Quantity:
E-AB-22075-200uL200uL£344.00
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: China.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Abbreviation:
EGFR
Background:
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.Isoform 2 may act as an antagonist of EGF action.
Buffer:
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Calculated MW:
134kDa
Concentration:
1 mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:1000-3000
Immunogen:
Synthetic Peptide
ObservedMW:
170kDa
Purification method:
Protein A purification
Target Synonym:
Avian erythroblastic leukemia viral (v erb b) oncogene homolog;Cell growth inhibiting protein 40;Cell proliferation inducing protein 61;EGF R;EGFR;EGFR;Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog);Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian);Epidermal growth factor receptor;erb-b2 receptor tyrosine kinase 1;ERBB;ERBB1;Errp;HER1;mENA;NISBD2;Oncogen ERBB;PIG61;Proto-oncogene c-ErbB-1;Receptor tyrosine protein kinase ErbB 1;Receptor tyrosine-protein kinase ErbB-1;SA7;Species antigen 7;Urogastrone;v-erb-b Avian erythroblastic leukemia viral oncogen homolog;wa2;Wa5
UNIProt ID:
P00533

Documents