Elabscience

HTRA1 Polyclonal Antibody

Product Code:
 
E-AB-40659
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze / thaw cycles.
1 / 1
Western blot with HTRA1 Polyclonal antibody at dilution of 1:500.lane 1:Mouse placenta, lane 2:Rat placenta
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Western blot with HTRA1 Polyclonal antibody at dilution of 1:500.lane 1:Mouse placenta, lane 2:Rat placenta

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E-AB-40659-50uL50uL£160.00
Quantity:
E-AB-40659-100uL100uL£230.00
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This product comes from: China.
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Further Information

Abbreviation:
HTRA1
Background:
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH 7.4
Calculated MW:
51 kDa
Concentration:
1.5mg/mL
Conjugation:
Unconjugated
Dilution:
WB:1:250-1:500
Immunogen:
Recombinant Human HTRA1 protein expressed by E.coli
ObservedMW:
51 kDa
Purification method:
Antigen Affinity Purification
Target Synonym:
Serine protease HTRA1; High-temperature requirement A serine peptidase 1; L56; Serine protease 11; PRSS11
UNIProt ID:
Q92743

Documents