Elabscience

YTHDF1 Polyclonal Antibody

Product Code:
 
E-AB-93227
Product Group:
 
Primary Antibodies
Supplier:
 
Elabscience
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Application:
 
Western Blot (WB)
Shipping:
 
Ice packs
Storage:
 
Store at -20°C. Avoid freeze/thaw cycles.
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Western blot analysis of extracts of various cell lines using YTHDF1 Polyclonal Antibody at 1:1000 dilution.
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Western blot analysis of extracts of various cell lines using YTHDF1 Polyclonal Antibody at 1:1000 dilution.

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E-AB-93227-60uL60uL£210.00
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E-AB-93227-120uL120uL£291.00
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E-AB-93227-200uL200uL£431.00
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This product comes from: China.
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Further Information

Abbreviation:
YTHDF1
Background:
Specifically recognizes and binds N6-methyladenosine (m6A-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3 shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity.
Buffer:
PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Calculated MW:
20kDa/60kDa
Concentration:
1mg/mL
Conjugation:
Unconjugated
Dilution:
WB 1:500-1:2000,IHC 1:50-1:200
Immunogen:
Recombinant fusion protein of human YTHDF1
ObservedMW:
70KDa
Purification method:
Affinity purification
Target Synonym:
YTHDF1;C20orf21
UNIProt ID:
Q9BYJ9

Documents