Elabscience

Recombinant Human VEGFR3/FLT4 Protein (His Tag)(Active)

Product Code:
 
PKSH031419
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Human
Regulatory Status:
 
RUO
Application:
 
Enzyme-Linked Immunosorbent Assay (ELISA)
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSH031419-100ug100ug£664.00
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This product comes from: China.
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Further Information

Abbreviation:
VEGFR3;FLT4
Accession:
NP_002011.2
Activity:
Measured by its binding ability in a functional ELISA. Immobilized human VEGF-C at 10 ug/mL (100 ul/well) can bind human VEGFR3-his. The EC50 of human VEGFR3-his is 0.011 ug/mL. Measured by its ability to bind human VEGF-D in a functional ELISA.
Background:
Vascular endothelial growth factor receptor 3 (VEGFR3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). The VEGFR3 protein is expressed mainly on lymphatic vessels but it is also up-regulated in tumor angiogenesis. Mutations in VEGFR3 have been identified in patients with primary lymphoedema. The VEGF-C/VEGF-D/VEGFR3 signaling pathway may provide a target for antilymphangiogenic therapy in prostate cancer, breast cancer, gastric cancer, lung cancer, non-small cell lung cancer (NSCLC), and so on.
Calculated MW:
86 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
HEK293 Cells
Formulation:
Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
C-His
ObservedMW:
130 kDa
Purity:
> 97 % as determined by reducing SDS-PAGE.
Sequence:
Met 1-Ile 776
Target Synonym:
FLT-4;FLT-41;FLT41;LMPH1A;PCL;VEGF Receptor 3;VEGFR-3;VEGFR3

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