Elabscience

Recombinant 2019-nCoV Papain-like Protease Protein (His Tag)

Product Code:
 
PKSR030511
Product Group:
 
Recombinant Proteins
Supplier:
 
Elabscience
Host Type:
 
Virus
Regulatory Status:
 
RUO
Shipping:
 
This product is provided as lyophilized powder which is shipped with ice packs.
Storage:
 
Generally lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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PKSR030511-100ug100ug£964.00
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This product comes from: China.
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Further Information

Abbreviation:
Papain-like Protease
Accession:
YP_009725299.1
Activity:
Measured by its ability to cleave a fluorogenic peptide substrate, Arg-Leu-Arg-Gly-Gly-AMC (RLRGGAMC). The Specific Activity is > 80pmols/min/ug
Background:
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
Calculated MW:
36.79 kDa
Endotoxin:
< 1.0 EU per ug of the protein as determined by the LAL method.
Expression Host:
E.coli
Formulation:
Lyophilized from sterile 20 mM Tris 500mM NaCl, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Fusion tag:
N-6His
Purity:
> 90 % as determined by reducing SDS-PAGE.
Sequence:
Glu1564-Val1880
Target Synonym:
Papain-like Protease;PLpro;PL-PRO;pp1a;Replicase polyprotein 1a

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