NSJ Bioreagents

Integrin beta 3 Antibody / ITGB3 / CD61

Product Code:
 
NSJ-V3255SAF
Product Group:
 
Primary Antibodies
Supplier:
 
NSJ Bioreagents
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1 kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
Y2/51
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry (IHC)
Storage:
 
Store the CD61 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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IHC testing of FFPE human spleen tissue with CD61 antibody (clone Y2/51). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.~
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SDS-PAGE Analysis of Purified, BSA-Free CD61 Antibody (clone Y2/51). Confir
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IHC testing of FFPE human spleen tissue with CD61 antibody (clone Y2/51). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.~
SDS-PAGE Analysis of Purified, BSA-Free CD61 Antibody (clone Y2/51). Confir

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NSJ-V3255SAF-100UG100 ug£534.00
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Further Information

Application Details:
Immunohistochemistry (Frozen & FFPE): 1-2ug/ml for 30 min at RT
Application Note:
Titration of the CD61 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Description:
Reacts with human CD61, also called Integrin beta 3 (GPIIIa, vitronectin receptor beta chain). It associates with the αV-chain (CD51) to form vitronectin receptor, or with the αIIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61). The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
Format:
Purified
Formulation:
1 mg/ml in 1X PBS; BSA free, sodium azide free
Immunogen:
Phytohemagglutinin (PHA)-stimulated peripheral blood cells were used as the immunogen for the CD61 antibody.
Limitation:
This CD61 antibody is available for research use only.
Localization:
Cell surface, cytoplasmic
Purity:
Protein G affinity
Uniprot #:
P05106

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