TMEPAI Antibody / PMEPA1

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT (1)

Optimal dilution of the TMEPAI antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

PMEPA1 (prostate transmembrane protein, androgen induced 1), or TMEPAI (Transmembrane prostate androgen induced protein) is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1/TMEPAI interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of TMEPAI is observed in prostate tumors, suggesting that TMEPAI may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Full-length recombinant human protein was used as the immunogen for the TMEPAI antibody.

This TMEPAI antibody is available for research use only.

Cell surface, cytoplasm

Protein G affinity chromatography

Q969W9