GPRC5A Antibody / Retinoic acid-induced protein 3 / PEIG-1

Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Retinoic acid-induced protein 3 (RAI3), also called Phorbol ester induced gene 1 (PEIG-1) and GPRC5A, is an transmembrane G protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. PEIG-1 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate PEIG-1 during its transcription in embryonal carcinoma differentiation. PEIG-1 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of PEIG-1 and represses its expression at the beginning of apoptosis. PEIG-1 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from PEIG-1 may have a place in breast cancer treatments.

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

A recombinant partial protein sequence (within amino acids 200-357) from the human protein was used as the immunogen for the PEIG-1 antibody.

This PEIG-1 antibody is available for research use only.

Cell membrane, Cytoplasmic

Protein A/G affinity

Q8NFJ5