CFTR Antibody / Cystic Fibrosis Transmembrane Regulator

Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Recognizes a protein of 165-170kDa, identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD), and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3',5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland, and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

A recombinant partial protein sequence (within amino acids 550-850) from the human protein was used as the immunogen for the Cystic Fibrosis Transmembrane Regulator antibody.

This Cystic Fibrosis Transmembrane Regulator antibody is available for research use only.

Cell surface, Cytoplasm

Protein A/G affinity

P13569