Cyclolinopeptide A

Product Code:

TAR-TP2377

Product Group:

Peptides

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20°C

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Code	Size	Price

TAR-TP2377-100mg

100mg

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Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.

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TAR-TP2377-500mg

500mg

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Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.

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Further Information

Bioactivity:

Cyclolinopeptide A is a cyclic nonapeptide extracted from linseed oil.

CAS:

33302-55-5

Molecular Weight:

1040.361

Purity:

0.98

SMILES:

[H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)C(NC(=O)[C@H](CC(C)C)NC(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC2=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C |@@:76|

Documents

References

Huben K, Jewgi?ski M, Pabis A, Paluch P, Luy B, Jankowski S. The structure of cyclolinopeptide A in chloroform refined by RDC measurements. J Pept Sci. 2014 Nov;20(11):901-7. doi: 10.1002/psc.2683. Epub 2014 Aug 11. PubMed PMID: 25111589. Wieczorek Z, Pedyczak A, Bodalski T, Lisowski M, Trojnar J, Zimecki M, Siemion IZ. Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A. Arch Immunol Ther Exp (Warsz). 1992;40(3-4):213-6. PubMed PMID: 1300986. Gaymes TJ, Cebrat M, Siemion IZ, Kay JE. Cyclolinopeptide A (CLA) mediates its immunosuppressive activity through cyclophilin-dependent calcineurin inactivation. FEBS Lett. 1997 Nov 24;418(1-2):224-7. PubMed PMID: 9414131. J?drzejczak K, Hrynczyszyn P, Artym J, Koci?ba M, Zimecki M, Zabrocki J, Jankowski S. Synthesis and biological activity of cyclolinopeptide A analogues modified with ?(3)-bis(homophenylalanine). Eur J Med Chem. 2014 Oct 30;86:515-27. doi: 10.1016/j.ejmech.2014.09.014. Epub 2014 Sep 6. PubMed PMID: 25203781.