AdipoGen Life Sciences

CTRP5 (human) (rec.) (His)

Product Code:
 
AG-40A-0142
Product Group:
 
Recombinant Proteins
Host Type:
 
E.coli
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Blue Ice
Storage:
 
-20°C
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Recombinant human CTRP5 (Prod. No. AG-40A-0142) activates AMPK signaling pathway in rat L6 myoblastes. Differentiated rat L6 myoblastes were stimulated with control buffer or 0.5?g/ml recombinant human CTRP5 for 30min. The cell lysate was subjec
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Recombinant human CTRP5 (Prod. No. AG-40A-0142) activates AMPK signaling pathway in rat L6 myoblastes. Differentiated rat L6 myoblastes were stimulated with control buffer or 0.5?g/ml recombinant human CTRP5 for 30min. The cell lysate was subjec

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AG-40A-0142-C01010 ug£180.00
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AG-40A-0142-C05050 ug£450.00
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Further Information

Alternate Names/Synonyms:
Complement C1q Tumor Necrosis Factor-related Protein 5; C1QTNF5
EClass:
32160000
Endotoxin:
<1EU/µg purified protein (LAL test; Lonza).
Form (Short):
liquid
Formulation:
Lyophilized from a 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.
Long Description:
Protein. Human CTRP5 (aa 16-243) is fused at the N-terminus to a His-tag. Source: E. coli. Endotoxin content: <1EU/µg purified protein (LAL test; Lonza). Lyophilized from a 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. Purity: >90% (SDS-PAGE). CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).
Molecular Weight:
~26kDa (SDS-PAGE)
NCBI, Uniprot Number:
Q9BXJ0
Package Type:
Plastic Vial
Product Description:
CTRP5 (C1qTNF-related protein 5; C1QTNF5) belongs to a highly conserved family of adiponectin paralogs. CTRP5 mediates activation of AMP-activated protein kinase (AMPK) in muscle and liver cells, thereby regulating glucose and lipid metabolism. Serum levels of CTRP5 are significantly higher in obese/diabetic animal models compared to normal controls. Furthermore, CTRP5 may be a putative biomarker for mitochondrial dysfunction. Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD).
Purity:
>90% (SDS-PAGE)
Sequence:
Human CTRP5 (aa 16-243) is fused at the N-terminus to a His-tag.
Source / Host:
E. coli
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

References

CTRP5 promotes transcytosis and oxidative modification of low-density lipoprotein and the development of atherosclerosis: C. Li, et al.; Atherosclerosis 278, 197 (2018)