AdipoGen Life Sciences

anti-Notch1 (mouse) mAb (22E5) (Biotin)

Product Code:
 
AG-20B-0051B
Product Group:
 
Primary Antibodies
Antibody Clonality:
 
Monoclonal
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Fluorescence-activated cell sorting (FACS)
Shipping:
 
-20°C
Storage:
 
-20°C
 

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AG-20B-0051B-C100100 ug£260.00
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Further Information

Alternate Names/Synonyms:
Neurogenic Locus Notch Homolog Protein 1; Motch A; mT14; p300
Concentration:
0.5mg/ml
EClass:
32160000
Form (Short):
liquid
Formulation:
Liquid. In PBS containing 0.02% sodium azide.
Handling Advice:
After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.
Immunogen:
Recombinant mouse Notch1:Fc (AG-40B-0109).
Labels - Conjugates:
Biotin
Long Description:
Monoclonal Antibody. Recognizes endogenous mouse Notch-1 receptor. Isotype: Rat IgG2akappa. Clone: 2.20E+06. Applications: FACS. Liquid. In PBS containing 0.02% sodium azide. Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
NCBI, Uniprot Number:
Q01705
Package Type:
Plastic Vial
Product Description:
Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
Purity:
>95% (SDS-PAGE)
Source / Host:
Purified from concentrated hybridoma tissue culture supernatant.
Specificity:
Recognizes endogenous mouse Notch-1 receptor.
Transportation:
Non-hazardous
UNSPSC Category:
Primary Antibody Conjugates
UNSPSC Number:
12352203
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.

References

Dynamic Regulation of Notch 1 and Notch 2 Surface Expression during T Cell Development and Activation Revealed by Novel Monoclonal Antibodies: E. Fiorini, et al.; J. Immunol.183, 7212 (2009) | Cutting edge: Thymic NK cells develop independently from T cell precursors: V.S. Ribeiro, et al.; J. Immunol. 185, 4993 (2010)