AdipoGen Life Sciences

POP1 (human) (rec.)

Product Code:
 
AG-40B-0123
Product Group:
 
Recombinant Proteins
Regulatory Status:
 
RUO
Target Species:
 
Human
Shipping:
 
Blue Ice
Storage:
 
+4°C
 

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CodeSizePrice
AG-40B-0123-C01010 ug£145.00
Quantity:
AG-40B-0123-30103 x 10 ug£280.00
Quantity:
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Pyrin Domain-containing Protein 1; PAAD-only Protein 1; Pyrin-only Protein 1; PYC1
Concentration:
0.1mg/ml after reconstitution.
EClass:
32160000
Form (Short):
liquid
Formulation:
Lyophilized. Contains PBS.
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Human POP1 (aa 2-89) is fused at the N-terminus to a GST tag. Source: E. coli. Lyophilized. Contains PBS. Purity: >95% (SDS-PAGE). The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.
Molecular Weight:
~38 kDa
NCBI, Uniprot Number:
Q8WXC3
Package Type:
Plastic Vial
Product Description:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.
Purity:
>95% (SDS-PAGE)
Sequence:
Human POP1 (aa 2-89) is fused at the N-terminus to a GST tag.
Source / Host:
E. coli
TAGs:
GST
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.