Ganglioside GD1a . disodium salt (bovine brain)

GD1a . 2Na; Disialoganglioside GD1a . 2Na

12707-58-3

32160000

Not detectable.

liquid

Lyophilized.

Hygroscopic.Protect from moisture.

InChI=1S/C84H148N4O39.2Na/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-58(103)88-48(49(98)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2)44-116-78-67(109)65(107)70(55(41-92)118-78)121-80-69(111)76(127-84(82(114)115)37-51(100)60(86-46(4)96)75(126-84)63(105)53(102)39-90)72(57(43-94)120-80)122-77-61(87-47(5)97)73(64(106)54(40-91)117-77)123-79-68(110)66(108)71(56(42-93)119-79)124-83(81(112)113)36-50(99)59(85-45(3)95)74(125-83)62(104)52(101)38-89;;/h32,34,48-57,59-80,89-94,98-102,104-111H,6-31,33,35-44H2,1-5H3,(H,85,95)(H,86,96)(H,87,97)(H,88,103)(H,112,113)(H,114,115);;/q;2*+1/p-2/b34-32+;;/t48-,49+,50?,51?,52+,53+,54?,55?,56?,57?,59+,60+,61?,62-,63-,64-,65?,66?,67?,68?,69?,70+,71-,72-,73?,74?,75?,76?,77+,78+,79-,80-,83+,84-;;/m0./s1

RLDNBFLGJKPAGV-GLORMQLTSA-L

Chemical. CAS: 12707-58-3. Formula: C84H146N4O39 . 2Na. MW: 1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid). Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1a is the major ganglioside of the nervous system. It is converted to GM1 by bacterial, viral and mammalian sialidases. It is a differentiation marker for cell growth.

MFCD00130960

C84H146N4O39 . 2Na

1836.1 . 46.0 (calculated on sphingosine C18:1 and stearic acid)

Glass Vial

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GD1a is the major ganglioside of the nervous system. It is converted to GM1 by bacterial, viral and mammalian sialidases. It is a differentiation marker for cell growth.

>98% (TLC)

Structure: IV3Neu5AcII3NeuAcGgOse4Cer; alpha-Neu5Ac-(2-3)-beta-Gal-(1-3)-beta-GalNAc-(1-4)-[alpha-Neu5Ac-(2-3)-]beta-Gal-(1-4)-beta-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 to 1:3 by vol.; stearic acid over 90%

[Na+].[Na+].[H][C@@](O)(CO)[C@]([H])(O)C1O[C@@](CC(O)[C@H]1NC(C)=O)(O[C@@H]1C(O)C(O)[C@H](OC2[C@@H](O)[C@H](CO)O[C@H](O[C@H]3C(CO)O[C@@H](O[C@H]4C(O)C(O)[C@H](OC[C@]([H])(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)C=CCCCCCCCCCCCCC)O[C@H]4CO)C(O)[C@H]3O[C@@]3(CC(O)[C@@H](NC(C)=O)C(O3)[C@@]([H])(O)[C@]([H])(O)CO)C([O-])=O)C2NC(C)=O)O[C@H]1CO)C([O-])=O

Soluble in water (micellar aggregates) or chloroform:methanol (2:1).

Isolated from bovine brain.

Non-hazardous

Glycolipids/Phospholipids/Sphingolipids

12352211

Stable for at least 2 years after receipt when stored at -20°C.