AdipoGen Life Sciences

Asialo-GM1

Product Code:
 
AG-CN2-9008
Product Group:
 
Lipids
Regulatory Status:
 
RUO
Shipping:
 
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Chemical Structure
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Chemical Structure

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AG-CN2-9008-C500500 ug£150.00
Quantity:
AG-CN2-9008-M0011 mg£240.00
Quantity:
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
Ceramide tetrahexoside; Gangliotetraosylceramide; Asialoganglioside-GM1
CAS:
71012-19-6
EClass:
32160000
Endotoxin:
Not detectable.
Form (Short):
liquid
Formulation:
Lyophilized.
Handling Advice:
Hygroscopic.Protect from moisture.
InChi:
InChI=1S/C62H114N2O23/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-46(71)64-40(41(70)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2)38-80-60-54(78)51(75)57(44(36-67)83-60)86-62-55(79)52(76)56(45(37-68)84-62)85-59-47(63-39(3)69)58(49(73)43(35-66)81-59)87-61-53(77)50(74)48(72)42(34-65)82-61/h30,32,40-45,47-62,65-68,70,72-79H,4-29,31,33-38H2,1-3H3,(H,63,69)(H,64,71)/b32-30+/t40-,41+,42?,43?,44?,45?,47?,48+,49-,50?,51?,52?,53?,54?,55?,56-,57+,58?,59+,60+,61-,62-/m0/s1
InChiKey:
VELGMVLNORPMAO-QZBQRYCTSA-N
Long Description:
Chemical. CAS: 71012-19-6. Formula: C62H114N2O23. MW: 1255.6 (calculated on sphingosine C18:1 and stearic acid). Semisynthetic. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Removing the sialic acid from monosialoganglioside GM1 inhibits its ability to bind cholera toxin. Asialo-ganglioside GM1 does not block the binding of cholera toxin to cellular GM1.
MDL:
MFCD29045295
Molecular Formula:
C62H114N2O23
Molecular Weight:
1255.6 (calculated on sphingosine C18:1 and stearic acid)
Package Type:
Glass Vial
Product Description:
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Removing the sialic acid from monosialoganglioside GM1 inhibits its ability to bind cholera toxin. Asialo-ganglioside GM1 does not block the binding of cholera toxin to cellular GM1.
Purity:
>98% (TLC)
Sequence:
Structure: GgOse4Cer; beta-Gal-(1-3)-beta-GalNAc-(1-4)-beta-Gal-(1-4)-beta-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 by vol.; stearic acid over 90%
SMILES:
[H][C@@](CO[C@@H]1O[C@@H](CO)[C@@H](O[C@@H]2OC(CO)[C@H](O[C@H]3O[C@@H](CO)[C@H](O)C(O[C@@H]4OC(CO)[C@@H](O)[C@H](O)C4O)C3NC(C)=O)[C@H](O)C2O)C(O)C1O)(NC(=O)CCCCCCCCCCCCCCCCC)[C@]([H])(O)C=CCCCCCCCCCCCCC
Solubility Chemicals:
Soluble in chloroform:methanol (2:1).
Source / Host:
Semisynthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Glycolipids/Phospholipids/Sphingolipids
UNSPSC Number:
12352211
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.

References

Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982)