ProSci

Caspase-7 Antibody

Product Code:
 
PSI-3465
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
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Western blot analysis of Caspase-7 in human skeletal muscle cell lysate with Caspase-7 antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.
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Immunohistochemical staining of human skeletal muscle using Caspase-7 antibody at 2 μg/mL.
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Western blot analysis of Caspase-7 in human skeletal muscle cell lysate with Caspase-7 antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.
Immunohistochemical staining of human skeletal muscle using Caspase-7 antibody at 2 μg/mL.

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CodeSizePrice
PSI-3465-0.02mg0.02mg£150.00
Quantity:
PSI-3465-0.1mg0.1mg£449.00
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Further Information

Additional Names:
Caspase-7 Antibody: MCH3, CMH-1, LICE2, CASP-7, ICE-LAP3, MCH3, Caspase-7, Apoptotic protease Mch-3
Application Note:
Casp-7 antibody can be used for the detection of Caspase-7 by Western blot at 0.5 to 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
Caspase-7 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression.
Background References:
  • Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.
  • Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.
  • Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.
  • Juan TSC, McNiece IK, Argento JM, et al. Identification and mapping of Casp7, a cysteine protease resembling CPP32b, Interleukin-1b converting enzyme, and CED-3. Genomics 1997; 40:86-93.
Buffer:
Caspase-7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Caspase-7 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Caspase-7.

The immunogen is located within the last 50 amino acids of Caspase-7.
NCBI Gene ID #:
840
NCBI Official Name:
caspase 7, apoptosis-related cysteine peptidase
NCBI Official Symbol:
CASP7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P55210
Protein GI Number:
1730092
Purification:
Caspase-7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis,Neuroscience,Cancer
SPECIFICITY:
Depending on cell lines or tissues used, other cleavage products may be observed.
Swissprot #:
P55210
User NOte:
Optimal dilutions for each application to be determined by the researcher.