ProSci

PRTFDC1 Antibody

Product Code:
 
PSI-4775
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
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Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.
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Western blot analysis of PRTFDC1 in human brain tissue lysate with PRTFDC1 antibody at 1 μg/mL in the (A) absence and (B) presence of blocking peptide.

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CodeSizePrice
PSI-4775-0.02mg0.02mg£150.00
Quantity:
PSI-4775-0.1mg0.1mg£449.00
Quantity:
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Further Information

Additional Names:
PRTFDC1 Antibody: HHGP, HHGP, Phosphoribosyltransferase domain-containing protein 1
Application Note:
PRTFDC1 antibody can be used for detection of PRTFDC1 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
PRTFDC1 Antibody: Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
Background References:
  • Nicklas JA. Pseudogenes of the human HPRT1 gene. Environ. Mol. Mutagen2006; 47:212-8.
  • Keebaugh AC, Sullivan RT, NISC Comparative Sequencing Program, et al. Gene duplication and inactivation in the HPRT gene family. Genomics2007; 89:134-42.
  • Cai LY, Abe M, Izumi S, et al. Identification of PRTFDC1 silencing and aberrant promoter methylation of GPR150, ITGA8 and HOXD11 in ovarian cancers. Life Sci.2007; 80:1458-65.
  • Suzuki E, Imoto I, Pimkhaokham A, et al. PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinoma by aberrant promoter hypermethylation. Oncogene2007; 26:7921-32.
Buffer:
PRTFDC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (86%), Pig: (86%), Bovine: (86%), Mouse: (86%)
Immunogen:
PRTFDC1 antibody was raised against a 14 amino acid synthetic peptide from near the center of human PRTFDC1.

The immunogen is located within amino acids 90 - 140 of PRTFDC1.
NCBI Gene ID #:
56952
NCBI Official Name:
phosphoribosyl transferase domain containing 1
NCBI Official Symbol:
PRTFDC1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_064585
Protein GI Number:
9910262
Purification:
PRTFDC1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q9NRG1
User NOte:
Optimal dilutions for each application to be determined by the researcher.