Chemodex

Hoechst 34580

Product Code:
 
CDX-B0094
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
+4 °C
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Chemical Structure
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Chemical Structure

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CDX-B0094-M0055 mg£72.00
Quantity:
CDX-B0094-M05050 mg£377.00
Quantity:
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
HOE 34580 . 3HCl; N,N-Dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]benzenamine trihydrochloride
Appearance:
Dark yellow solid.
CAS:
911004-45-023555-00-2 (free base)
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light and moisture.
InChi:
InChI=1S/C27H29N7.3ClH/c1-32(2)20-7-4-18(5-8-20)26-28-22-10-6-19(16-24(22)30-26)27-29-23-11-9-21(17-25(23)31-27)34-14-12-33(3)13-15-34;;;/h4-11,16-17H,12-15H2,1-3H3,(H,28,30)(H,29,31);3*1H
InChiKey:
IPMZLKUUQSFUTA-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 911004-45-023555-00-2 (free base). Formula: C27H29N7 . 3HCl. MW: 561. Synthetic. The Hoechst stains are a family of fluorescent stains for labeling DNA in fluorescence microscopy. The blue fluorescent Hoechst dye is a cell permeable nucleic acid stain that has multiple applications, including sensitive detection of DNA in the presence of RNA in agarose gels, automated DNA determination, sensitive determination of cell number and chromosome sorting. Useful vital stain for the flow cytometric recognition of DNA damage and other viability measurements by monitoring the emission spectral shifts of the dyes. Because this fluorescent stain labels DNA, it can also be used to visualize nuclei and mitochondria. Hoechst 34580 can be excited by violet laser at 405 nm, and emit blue/cyan fluorescence light around an emission maximum at ~440 nm. It is cell-permeable and an excellent tool for flow cytometry studies.
MDL:
MFCD24849290
Molecular Formula:
C27H29N7 . 3HCl
Molecular Weight:
561
Package Type:
Vial
Product Description:
The Hoechst stains are a family of fluorescent stains for labeling DNA in fluorescence microscopy. The blue fluorescent Hoechst dye is a cell permeable nucleic acid stain that has multiple applications, including sensitive detection of DNA in the presence of RNA in agarose gels, automated DNA determination, sensitive determination of cell number and chromosome sorting. Useful vital stain for the flow cytometric recognition of DNA damage and other viability measurements by monitoring the emission spectral shifts of the dyes. Because this fluorescent stain labels DNA, it can also be used to visualize nuclei and mitochondria. Hoechst 34580 can be excited by violet laser at 405 nm, and emit blue/cyan fluorescence light around an emission maximum at ~440 nm. It is cell-permeable and an excellent tool for flow cytometry studies.
Purity:
>98% (HPLC)
SMILES:
CCCCCCCC(=O)OC1=CC2=C(C=C1)C=C(C1=NC3=C(O1)C=CC=C3)C(=O)O2
Solubility Chemicals:
Soluble in DMSO, DMF or water (1mg/ml).
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at +4°C.

References

(1) S.A. Latt & G. Stetten; J. Histochem. Cytochem. 24, 24 (1976) | (2) D.P. Kelly, et al.; Aus. J. Chem. 47, 1751 (1994) | (3) W.G. Telford, et al.; Cytometry A. 54, 48 (2003) | (4) D.A. Evans & S. Neidle; J. Med. Chem. 49, 4232 (2006) | (5) W. Lei, et al.; ChemPhysChem 12, 2933 (2011)