ProSci

IRS-1 Antibody

Product Code:
 
PSI-79-210
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
  • Rat
Applications:
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
 
Store antibody at -20˚C for up to one year.
1 / 2
Western blot analysis of lysed extracts from 293 cells untreated or treated with serum using IRS-1 (Phospho-Ser639).
2 / 2
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IRS-1 (Phospho-Ser639).
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Western blot analysis of lysed extracts from 293 cells untreated or treated with serum using IRS-1 (Phospho-Ser639).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IRS-1 (Phospho-Ser639).

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PSI-79-210-0.1mg0.1mg£488.00
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Further Information

Additional Names:
HIRS-1, NFKB3, IRS-1, IRS1
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Background:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
Background References:
  • Ozes ON, et al. (2001) Proc Natl Acad Sci U S A; 98 (8): 4640-4645Tzatsos A, et al. (2006) Mol Cell Biol; 26 (1): 63-76Steppan CM, et al. (2005) Mol Cell Biol; 25 (4): 1569-1575Batty IH, et al. (2004) Biochem J; 379 (Pt 3): 641-651
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IRS-1 (Phospho-Ser639) antibody was raised against a peptide sequence around phosphorylation site of serine 639 (P-K-S (p) -V-S) derived from Human IRS-1.
Modifications:
Phospho-Specific
NCBI Gene ID #:
3667
NCBI Official Name:
insulin receptor substrate 1
NCBI Official Symbol:
IRS1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
180 kDa
Protein Accession #:
NP_005535.1
Protein GI Number:
5031805
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Research Area:
Phospho-Specific
SPECIFICITY:
This antibody detects endogenous level of IRS-1 only when phosphorylated at serine 639.
Swissprot #:
P35568