ProSci

sCD100 Recombinant Protein

Product Code:
 
PSI-40-530
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized sCD100 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted sCD100 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
 

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CodeSizePrice
PSI-40-530-0.005mg0.005mg£300.00
Quantity:
PSI-40-530-0.02mg0.02mg£428.00
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Further Information

Additional Names:
CD100, SEMAJ, coll-4, C9orf164, M-sema-G, CD100, Semaphorin-4D, A8
Background:
The Semphorins are a large family of phylogenetically conserved proteins that play a pivotal role in maintaining homeostasis in the immune system. Twenty members of this family have been identified and categorized into eight subclasses based on sequence similarity and distinctive structural features. CD100, also known as Sema4D, is a 150 kDa transmembrane class IV semaphorin. Studies have shown that CD100 can induce monocyte migration, T-cell activation, and B-cell survival, as well as T/B cell and T/DC "cooperation?. The CD100 precursor contains 862 amino acids, including a 21 a.a. signal sequence, a 713 a.a. extracellular domain, a 21 a.a transmembrane sequence, and a 107 a.a cytoplasmic region. The extracellular sequence contains several structural features, including a 479 a.a "sema? domain, a 79 a.a. Ig-like sequence, and a 52 a.a "Plexin-type repeat?. Recombinant soluble CD100 is a 78.9 kDa protein comprising the extracellular domain of CD100 (711 amino acids). SDS-PAGE analysis run under non-reducing conditions shows a mixture of disulfide linked dimer and monomer.
Biological Activity:
Endotoxin level is less than 0.1 ng per ug (1EU/μg).
NCBI Gene ID #:
10507
NCBI Official Name:
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
NCBI Official Symbol:
SEMA4D
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_006369.3
Protein GI Number:
214010218
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
CHO cells
Swissprot #:
Q92854

Documents