ProSci

BMP-2 Recombinant Protein

Product Code:
 
PSI-40-106
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized BMP-2 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted BMP-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
 

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CodeSizePrice
PSI-40-106-0.002mg0.002mg£300.00
Quantity:
PSI-40-106-0.01mg0.01mg£428.00
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Further Information

Additional Names:
BDA2, BMP2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A, BMP-2
Background:
BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
Biological Activity:
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC - 5 cells. The expected ED50 for this effect is 0.5 - 1.0 μg/mL.
NCBI Gene ID #:
650
NCBI Official Name:
bone morphogenetic protein 2
NCBI Official Symbol:
BMP2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001191.1
Protein GI Number:
4557369
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P12643

Documents