ProSci

TIMP-1 Recombinant Protein

Product Code:
 
PSI-40-141
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized TIMP-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TIMP-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
 

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CodeSizePrice
PSI-40-141-0.002mg0.002mg£300.00
Quantity:
PSI-40-141-0.01mg0.01mg£428.00
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This product comes from: United States.
Typical lead time: 14-21 working days.
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Further Information

Additional Names:
EPA, EPO, HCI, CLGI, TIMP, Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA
Background:
TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors. Recombinant human TIMP-1 is a 20.6 kDa protein containing 184 amino acid residues.
Biological Activity:
TIMP1 activity was measured by its ability to inhibit human MMP - 1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP - 1 concentration of approximately 0.5 μg/mL, when using an MMP - 1 concentration of 1.6 μg/mL.
NCBI Gene ID #:
7076
NCBI Official Name:
TIMP metallopeptidase inhibitor 1
NCBI Official Symbol:
TIMP1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_003245.1
Protein GI Number:
4507509
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P01033

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