ProSci

BD-4 Recombinant Protein

Product Code:
 
PSI-40-135
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized BD-4 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted BD-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
 

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CodeSizePrice
PSI-40-135-0.005mg0.005mg£300.00
Quantity:
PSI-40-135-0.02mg0.02mg£428.00
Quantity:
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Further Information

Additional Names:
BD-4, DEFB4, hBD-4, DEFB-4, DEFB104, DEFB104B, Beta-defensin 104, Beta-defensin 4, BD-4
Background:
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Recombinant human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.
Biological Activity:
Determined by its ability to chemoattract human monocytes using a concentration range of 0.1 - 100.0 ng/mL.
NCBI Gene ID #:
140596
NCBI Official Name:
defensin, beta 104A
NCBI Official Symbol:
DEFB104A
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_525128.2
Protein GI Number:
103485139
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q8WTQ1

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