ProSci

CYR61 Recombinant Protein

Product Code:
 
PSI-40-221
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized CYR61 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted CYR61 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, expos
 

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CodeSizePrice
PSI-40-221-0.005mg0.005mg£300.00
Quantity:
PSI-40-221-0.02mg0.02mg£428.00
Quantity:
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Further Information

Additional Names:
CCN1, GIG1, IGFBP10, CCN1, Protein CYR61, CCN family member 1, IBP-10
Background:
CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Biological Activity:
Biological activity was determined by the dose - dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0 - 3.0 μg/mL.
NCBI Gene ID #:
3491
NCBI Official Name:
cysteine-rich, angiogenic inducer, 61
NCBI Official Symbol:
CYR61
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001545.2
Protein GI Number:
31542331
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O00622

Documents