ProSci

FGF-23 Recombinant Protein

Product Code:
 
PSI-40-194
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized FGF-23 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted FGF-23 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exp
 

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CodeSizePrice
PSI-40-194-0.005mg0.005mg£300.00
Quantity:
PSI-40-194-0.02mg0.02mg£428.00
Quantity:
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Further Information

Additional Names:
ADHR, FGFN, HYPF, HPDR2, PHPTC, UNQ3027/PRO9828, Fibroblast growth factor 23, Phosphatonin, FGF-23
Background:
The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant human FGF-23 is a 22.5 kDa globular protein containing 228 amino acid residues.
Biological Activity:
Biological Activity was determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. The expected ED50 for this effect is 2.0-5.0 ug/ml, in the presence of murine Klotho and heparin
NCBI Gene ID #:
8074
NCBI Official Name:
fibroblast growth factor 23
NCBI Official Symbol:
FGF23
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_065689.1
Protein GI Number:
10190674
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q9GZV9

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