ProSci

Follistatin Recombinant Protein

Product Code:
 
PSI-40-211
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Follistatin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Follistatin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any pr
 

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CodeSizePrice
PSI-40-211-0.005mg0.005mg£300.00
Quantity:
PSI-40-211-0.02mg0.02mg£428.00
Quantity:
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Further Information

Additional Names:
FS, Follistatin, Activin-binding protein, FS
Background:
Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.
Biological Activity:
Biological activity was determined by its ability to neutralize Activin A inhibitory effect of murine MPC - 11 cells. The expected ED50is 0.1 - 0.4 μg/mL in the presence of 7.5 ng/mL Activin A.
NCBI Gene ID #:
10468
NCBI Official Name:
follistatin
NCBI Official Symbol:
FST
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_006341.1
Protein GI Number:
5453652
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P19883

Documents