ProSci

Soluble Fas Receptor Recombinant Protein

Product Code:
 
PSI-40-311
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized Soluble Fas Receptor recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble Fas Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°
 

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CodeSizePrice
PSI-40-311-0.005mg0.005mg£300.00
Quantity:
PSI-40-311-0.02mg0.02mg£428.00
Quantity:
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This product comes from: United States.
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Further Information

Additional Names:
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, APT1, Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen
Background:
Fas and Fas Ligand (FasL) belong to the TNF superfamily and are type I and type II transmembrane proteins, respectively. Binding of FasL to Fas triggers apoptosis in Fas-bearing cells. The mechanism of apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD followed by processing of the pro-enzyme to active forms. These active caspases then cleave various cellular substrates leading to the eventual cell death. sFasR is capable of inhibiting FasL-induced apoptosis by acting as a decoy receptor that serves as a sink for FasL. The full length Fas (receptor) is a 319 amino acid type I transmembrane protein, which contains a 157 amino acid extracellular domain, a 17 amino acid transmembrane domain, and 145 amino acid cytoplasmic domain. Recombinant human soluble Fas (sFas Receptor) is a 157 amino acid polypeptide (17.6 kDa) corresponding to the TNFR homologous cysteine rich extracellular domain Fas.
Biological Activity:
The ED50 was Biological activity was determined by its ability to inhibit the cytotoxicity of Jurkat cells is between 10 - 15 μg/mL in the presence of 2 ng/mL of hFasL.
NCBI Gene ID #:
355
NCBI Official Name:
Fas cell surface death receptor
NCBI Official Symbol:
FAS
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000034.1
Protein GI Number:
4507583
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P25445

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