ProSci

TACI Recombinant Protein

Product Code:
 
PSI-40-308
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized TACI recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TACI is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposin
 

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CodeSizePrice
PSI-40-308-0.005mg0.005mg£300.00
Quantity:
PSI-40-308-0.02mg0.02mg£428.00
Quantity:
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Further Information

Additional Names:
CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor
Background:
TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.
Biological Activity:
Biological activity was determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0 - 3.0 μg/mL.
NCBI Gene ID #:
23495
NCBI Official Name:
tumor necrosis factor receptor superfamily, member 13B
NCBI Official Symbol:
TNFRSF13B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_036584.1
Protein GI Number:
6912694
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
O14836

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