ProSci

CDNF Recombinant Protein

Product Code:
 
PSI-40-550
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized CDNF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted CDNF stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing C
 

No additional charges, what you see is what you pay! *

CodeSizePrice
PSI-40-550-0.005mg0.005mg£300.00
Quantity:
PSI-40-550-0.025mg0.025mg£428.00
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 14-21 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • Show All

Further Information

Additional Names:
ARMETL1, ARMETL1, Cerebral dopamine neurotrophic factor, ARMET-like protein 1
Background:
CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues.
Biological Activity:
Biological activity was determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/mL. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
NCBI Gene ID #:
441549
NCBI Official Name:
cerebral dopamine neurotrophic factor
NCBI Official Symbol:
CDNF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_001025125.2
Protein GI Number:
82880674
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
Q49AH0

Documents