ProSci

IGF-BP3 Recombinant Protein

Product Code:
 
PSI-40-153
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
The lyophilized IGF-BP3 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IGF-BP3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, e
 

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CodeSizePrice
PSI-40-153-0.005mg0.005mg£300.00
Quantity:
PSI-40-153-0.025mg0.025mg£428.00
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Further Information

Additional Names:
IBP3, BP-53, IBP3, Insulin-like growth factor-binding protein 3, IBP-3
Background:
IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
Biological Activity:
The ED50 was determined by its ability to inhibit IGF - II induced proliferation of MCF - 7. The expected ED50 for this effect is ≤ 0.2 μg/mL in presence of 15 ng/mL of human IGF - II.
NCBI Gene ID #:
3486
NCBI Official Name:
insulin-like growth factor binding protein 3
NCBI Official Symbol:
IGFBP3
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Protein Accession #:
NP_000589.2
Protein GI Number:
62243068
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Recombinant Protein Sequence:
#N/A
Source:
E. coli
Swissprot #:
P17936

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