ProSci

CD11b (activation epitope) Antibody [CBRM1/5]

Product Code:
 
PSI-76-115
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Mouse
Antibody Isotype:
 
Mouse IgG1, kappa
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
CBRM1/5
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Functional Study
Storage:
 
The product should be stored undiluted at 4°C. Do not freeze.
 

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PSI-76-115-0.1mg0.1mg£686.00
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Further Information

Additional Names:
CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM
Background:
The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules. The CBRM1/5 specifically reacts with the activation-specific epitope of the Mac-1 molecule, in the I domain on the alpha chain near the ligand binding site. The antibody has been reported to inhibit the cellular adhesion mediated by Mac-1.
Background References:
  • Oxvig, C., Lu, C., Springer, T. A. (1999). Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.Proceedings of the National Academy of Sciences,96(5), 2215-2220.
  • Diamond, M. S., Springer, T. A. (1993). A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.The Journal of cell biology,120(2), 545-556.
  • Shimaoka, M., Shifman, J. M., Jing, H., Takagi, J., Mayo, S. L., Springer, T. A. (2000). Computational design of an integrin I domain stabilized in the open high affinity conformation.Nature Structural Molecular Biology,7(8), 674-678.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
3684
NCBI Official Name:
integrin, alpha M (complement component 3 receptor 3 subunit)
NCBI Official Symbol:
ITGAM
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Innate Immunity
SPECIFICITY:
The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1.
Swissprot #:
P11215
User NOte:
Optimal dilutions for each application to be determined by the researcher.