ProSci

Trk A (phospho Tyr791) Antibody

Product Code:
 
PSI-79-778
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry (IHC)
Storage:
 
Store antibody at -20°C for up to one year.
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Immunohistochemical analysis of paraffin-embedded human brain tissue, using Trk A (phospho-Tyr791) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Immunohistochemical analysis of paraffin-embedded human brain tissue, using Trk A (phospho-Tyr791) antibody (left) or the same antibody preincubated with blocking peptide (right).

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PSI-79-778-0.1mg0.1mg£488.00
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Further Information

Additional Names:
TRKA, TRK, NTRK1, p140-TrkA
Background:
Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.
Background References:
  • Tina Garofalo, J. Biol. Chem., Dec 1998; 273: 35153.
  • Jan Grimm, J. Cell Biol., Jul 2001; 154: 345.
  • Jose L. Tomsig, J Androl, May 2006; 27: 348 - 357.
  • VI Shifrin and BG Neel J. Biol. Chem., Dec 1993; 268: 25376 - 25384
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
Trk A (phospho Tyr791) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y (p)-L-D) derived from Human Trk A.
Modifications:
Phospho-Specific
NCBI Gene ID #:
4914
NCBI Official Name:
neurotrophic tyrosine kinase, receptor, type 1
NCBI Official Symbol:
NTRK1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
140 kDa
Protein Accession #:
NP_002520.2
Protein GI Number:
94730402
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 791.
Swissprot #:
P04629