ProSci

IKK-γ (phospho Ser376) Antibody

Product Code:
 
PSI-79-846
Product Group:
 
Primary Antibodies
Supplier:
 
ProSci
Host Type:
 
Rabbit
Antibody Isotype:
 
IgG
Antibody Clonality:
 
Polyclonal
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Immunohistochemistry (IHC)
Storage:
 
Store antibody at -20°C for up to one year.
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Immunohistochemical analysis of paraffin-embedded human brain tissue using IKK-? (Phospho-Ser376) antibody (left) or the same antibody preincubated with blocking peptide (right).
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Immunohistochemical analysis of paraffin-embedded human brain tissue using IKK-? (Phospho-Ser376) antibody (left) or the same antibody preincubated with blocking peptide (right).

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PSI-79-846-0.1mg0.1mg£488.00
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Further Information

Additional Names:
FIP3, IKBKG, IKKAP1, IKKG, NF-kappaB
Background:
Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.
Background References:
  • Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).
  • Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).
  • Rothwarf D.M., Nature 395:297-300(1998).
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IKK-γ (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Y-L-S (p)-S-P) derived from Human IKK-γ.
Modifications:
Phospho-Specific
NCBI Gene ID #:
8517
NCBI Official Name:
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
NCBI Official Symbol:
IKBKG
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
48 kDa
Protein Accession #:
NP_001093327.1
Protein GI Number:
3641279
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Research Area:
Phospho-Specific
SPECIFICITY:
The antibody detects endogenous levels of IKK-? only when phosphorylated at serine 376.
Swissprot #:
Q9Y6K9