ProSci

SCARB1 Recombinant Protein

Product Code:
 
PSI-96-673
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-673-0.05mg0.05mg£686.00
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Further Information

Additional Names:
SCARB1, CD36L1, SRB1, CLA-1, SR-BI, HDLQTL6
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.
Background References:
  • Acton S., et al., 1996, Science 271 (5248): 518?20.
  • Duggan AE., et al., 2002, J. Exp. Zool. 292 (5): 430?4.
  • Kapadia SB., et al., 2007, J. Virol. 81 (1): 374?83.
  • Scarselli E., et al., 2002, EMBO J. 21:5017-5025.
Biological Activity:
Measured by its ability to bind recombinant Human ApoAI in a functional ELISA.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
949
NCBI Official Name:
scavenger receptor class B, member 1
NCBI Official Symbol:
SCARB1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
72.6 kDa
Protein Accession #:
NP_005496.4
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8WTV0

Documents