ProSci

Frizzled 4 Recombinant Protein

Product Code:
 
PSI-96-333
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-333-0.1mg0.1mg£626.00
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Further Information

Additional Names:
FZD4, Frizzled-4, CD344, Fz-4, hFz4, FzE4
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).
Background References:
  • Nallathambi J., et al., 2006, Mol. Vis. 12:1086-1092.
  • Sjoeblom T., et al., 2006, Science 314:268-274.
Buffer:
PBS, pH 7.4
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
8322
NCBI Official Name:
frizzled class receptor 4
NCBI Official Symbol:
FZD4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
42.9 kDa
Protein Accession #:
AAI14528
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9ULV1

Documents