ProSci

Apo A1 Recombinant Protein

Product Code:
 
PSI-96-031
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-031-0.05mg0.05mg£686.00
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Further Information

Additional Names:
Apolipoprotein A-I, APOA1, MGC117399
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.
Background References:
  • Wasan KM , et al. 2008, Nature Reviews Drug Discovery 7 : 84?99.
  • Yui Y, et al. 1988, J. Clin. Invest. 82 (3): 803?7.
  • Eggerman, T.L. et al., 1991, J. Lipid Res. 32: 821-828.
  • Voyiaziakis, E. et al., 1998. J. Lipid Res. 39: 313-321.
Biological Activity:
Immobilized Human ApoAI at 10μg/mL (100μl/well) can bind biotinylated human SCARB1. The EC50 of biotinylated human SCARB1 is 10-100 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
335
NCBI Official Name:
apolipoprotein A-I
NCBI Official Symbol:
APOA1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
29 kDa
Protein Accession #:
NP_000030.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P02647

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