ProSci

DIABLO Recombinant Protein

Product Code:
 
PSI-96-235
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Western Blot (WB)
Storage:
 
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
 

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PSI-96-235-0.2mg0.2mg£524.00
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Further Information

Additional Names:
DIABLO, SMAC
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Background References:
  • Du C., et al., 2000, Cell 102:33-42.
  • Fu J., et al., 2003, J. Biol. Chem. 278:52660-52672
  • Ma L., et al., 2006, Cell Death Differ. 13:2079-2088.
Buffer:
20 mM Hepes, 150 mM Nacl, pH7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
56616
NCBI Official Name:
diablo, IAP-binding mitochondrial protein
NCBI Official Symbol:
DIABLO
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
21.7 kDa
Protein Accession #:
NP_063940
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
Q9NR28

Documents