Chimerigen

B7-H3(4Ig) [B7-H3b] (human) (rec.) (His)

Product Code:
 
CHI-HF-201B7H3B
Product Group:
 
Recombinant Proteins
Supplier:
 
Chimerigen
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Activity Assay
Shipping:
 
BI
Storage:
 
+4°C(Short Term) -20°C(Long Term)
 

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CHI-HF-201B7H3B-C05050 ug£355.00
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This product comes from: Switzerland.
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Further Information

Biological Activity:
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
EClass:
32160000
Endotoxin:
<0.01EU/µg protein (LAL test; Lonza).
Form (Short):
solid
Formulation:
Lyophilized from 0.2µm-filtered solution in PBS.
Handling Advice:
Avoid freeze/thaw cycles.Centrifuge lyophilized vial before opening and reconstitution.PBS containing at least 0.1% BSA should be used for further dilutions.
Long Description:
Protein. Human B7-H3(4Ig) [B7-H3b] (aa 27-461) is fused at the C-terminus to a His-tag. Source: HEK 293 cells. Endotoxin content: <0.01EU/µg protein (LAL test; Lonza). Lyophilized from 0.2µm-filtered solution in PBS. Purity: >95% (SDS-PAGE). B7-H3(4Ig) or B7-H3b has two additional Ig-like domains (one V- type and one C- type) and shows a ubiquituous expression pattern. B7-H3(4Ig) is expressed on dendritic cells as well as activated T, B and NK cells. Human (4Ig) binding to an undefined receptor has shown to be inhibitory to NK cell illing and cytokine release. It also seems to be required for late stage osteoblast differentiation.
Molecular Weight:
~65kDa (SDS-PAGE)
NCBI, Uniprot Number:
NP_001019907.1
Package Type:
Plastic Vial
Product Description:
B7-H3(4Ig) or B7-H3b has two additional Ig-like domains (one V- type and one C- type) and shows a ubiquituous expression pattern. B7-H3(4Ig) is expressed on dendritic cells as well as activated T, B and NK cells. Human (4Ig) binding to an undefined receptor has shown to be inhibitory to NK cell illing and cytokine release. It also seems to be required for late stage osteoblast differentiation.
Purity:
>95% (SDS-PAGE)
Sequence:
Human B7-H3(4Ig) [B7-H3b] (aa 27-461) is fused at the C-terminus to a His-tag.
Source / Host:
HEK 293 cells
TAGs:
His
Transportation:
Non-hazardous
UNSPSC Category:
Other Proteins
UNSPSC Number:
12352202
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.