Further Information
Amiloride-sensitive amine oxidase [copper-containing], DAO, Diamine oxidase, Amiloride-binding protein 1, Amine oxidase copper domain-containing protein 1, Histaminase, Kidney amine oxidase, KAO, AOC1, ABP1, DAO1, ABP1, AOC1
This recombinant protein can be used for biological assays. For research use only.
Amiloride-sensitive amine oxidase (AOC1) belongs to the copper/topaquinone oxidase family. The protein exists as homodimer by disulfide and mainly located in placenta and kidney. AOC1 catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. The activity of this protein can be inhibited by amiloride in a competitive manner. It is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.
Supplied as a 0.2 um filtered solution of 20mM TrisHCl, 150mM NaCl,10% Glycerol,pH7.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
C-6 His tag
26
amine oxidase, copper containing 1
AOC1
Homo sapiens
Liquid
Predicted Molecular Weight:
84.4 kD
P19801
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Human Cells
P19801