ProSci

Endoglin Recombinant Protein

Product Code:
 
PSI-92-192
Product Group:
 
Recombinant Proteins
Supplier:
 
ProSci
Regulatory Status:
 
RUO
Target Species:
 
Human
Storage:
 
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
 

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PSI-92-192-0.05mg0.05mg£673.00
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Further Information

Additional Names:
Endoglin, END, CD105, ENG
Application Note:
This recombinant protein can be used for biological assays. For research use only.
Background:
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins and/or other RGD receptors. Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1), which is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations.
Buffer:
Supplied as a 0.2 um filtered solution of 20mM PB, 150mM NaCl,pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Fusion Tag:
N-Trx, 6 His tag
NCBI Gene ID #:
2022
NCBI Official Name:
endoglin
NCBI Official Symbol:
ENG
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Predicted Molecular Weight:
33.6 kD
Protein Accession #:
P17813
Protein GI Number:
325652083
Purity:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P17813

Documents