GSK429286A
| Code | Size | Price |
|---|
| SYN-1071-M100 | 100 mg | Enquire |
Quantity:
| SYN-1071-M001 | 1 mg | £115.00 |
Quantity:
| SYN-1071-M005 | 5 mg | £192.00 |
Quantity:
| SYN-1071-M010 | 10 mg | £279.00 |
Quantity:
| SYN-1071-M050 | 50 mg | £789.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
GSK-429286A; RHO-15
Appearance:
Solid.
CAS:
864082-47-3
EClass:
32160000
Form (Short):
liquid
InChi:
InChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)
InChiKey:
OLIIUAHHAZEXEX-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 864082-47-3. Formula: C21H16F4N4O2. MW: 432.4. GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats.
Molecular Formula:
C21H16F4N4O2
Molecular Weight:
432.4
Package Type:
Plastic Vial
Product Description:
GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats.
Purity:
>95%
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Protein Kinase Modulators
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease: R.J. Nichols, et al.; Biochem. J. 424, 47 (2009)
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