Chemodex

Zincon monosodium salt

Product Code:
 
CDX-Z0028
Product Group:
 
Dyes, Stains, and Probes
Supplier:
 
Chemodex
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
Short Term: +20°C. Long Term: +20°C
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Chemical Structure
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Chemical Structure

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CDX-Z0028-G0011 g£59.00
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CDX-Z0028-G0055 g£121.00
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This product comes from: Switzerland.
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Further Information

Alternate Names/Synonyms:
2-[5-(2-Hydroxy-5-sulfophenyl)-3-phenyl-1-formazyl]benzoic acid monosodium salt; 2-Carboxy-2'-hydroxy-5'-sulfoformazyl-benzene monosodium salt
Appearance:
Dark violet powder.
CAS:
62625-22-3
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Protect from light and moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C20H16N4O6S.Na/c25-18-11-10-14(31(28,29)30)12-17(18)22-24-19(13-6-2-1-3-7-13)23-21-16-9-5-4-8-15(16)20(26)27;/h1-12,21,25H,(H,26,27)(H,28,29,30);/q;+1/p-1/b23-19+,24-22+;
InChiKey:
DVHNWVSFUULGKM-SWJPHGMYSA-M
Long Description:
Chemical. CAS: 62625-22-3. Formula: C20H15N4NaO6S. MW: 462.41. Synthetic. A colorimetric reagent for Zn, Cu and Hg detection and a metal indicator in EDTA titration. The aqueous solution of Zincon is yellow or orange-yellow in weak alkaline conditions, and turns blue in the presence of Cu (maximum wavelength: 600nm, molar absorptivity: 1.9x104) and Zn (pH 8.5-9.5, maximum wavelength: 620nm, molar absorptivity: 23,000). Used for the spectrophotometric determination of zinc, simultaneous determination of zinc and copper and for automated flow injection spectrometric determination of zinc. Binds nonspecifically proteins at acidic pH and was therefore used to stain proteins fast and background-free in sodium dodecyl sulfate polyacrylamide gel (SDS-Page). Sligthly less sensitivity than Coomassie Brilliant Blue®CBB but stains and destains more rapidly. Additionally, zincon staining is reversible, suggesting it might be applicable to 2-D PAGE and downstream analyses by mass spectrometry. Shown to inhibit insulin binding to its receptor and to attenuate the activity of ATPase and other enzymes, presumably because of the chelating properties of the dye.
MDL:
MFCD00064385
Molecular Formula:
C20H15N4NaO6S
Molecular Weight:
462.41
Package Type:
Vial
Precautions:
P305, P351, P338
Product Description:
A colorimetric reagent for Zn, Cu and Hg detection and a metal indicator in EDTA titration. The aqueous solution of Zincon is yellow or orange-yellow in weak alkaline conditions, and turns blue in the presence of Cu (maximum wavelength: 600nm, molar absorptivity: 1.9x104) and Zn (pH 8.5-9.5, maximum wavelength: 620nm, molar absorptivity: 23,000). Used for the spectrophotometric determination of zinc, simultaneous determination of zinc and copper and for automated flow injection spectrometric determination of zinc. Binds nonspecifically proteins at acidic pH and was therefore used to stain proteins fast and background-free in sodium dodecyl sulfate polyacrylamide gel (SDS-Page). Sligthly less sensitivity than Coomassie Brilliant Blue®CBB but stains and destains more rapidly. Additionally, zincon staining is reversible, suggesting it might be applicable to 2-D PAGE and downstream analyses by mass spectrometry. Shown to inhibit insulin binding to its receptor and to attenuate the activity of ATPase and other enzymes, presumably because of the chelating properties of the dye.
Purity:
~85%
Signal word:
Warning
SMILES:
O=S(C1=CC=C(O)C(/N=N/C(C2=CC=CC=C2)=N/NC3=CC=CC=C3C(O)=O)=C1)([O-])=O.[Na+]
Solubility Chemicals:
Slightly soluble in water (20°C), alcohol or aqueous alkali. Insoluble in most organic solvents.
Source / Host:
Synthetic.
Transportation:
Non-hazardous
UNSPSC Category:
Fluorescent Reagents
UNSPSC Number:
41105331
Use & Stability:
Stable for at least 2 years after receipt when stored at +20°C.

References

(1) G.K. Singhal & K.N. Tandon; Talanta 14, 1351 (1967) | (2) K. Vytras, et al.; Talanta 22, 529 (1975) | (3) F. Mollinedo, et al.; Eur J Biochem. 119, 183 (1981) | (4) H. Ono & A. Ito; J. Biochem. 95, 345 (1984) | (5) M.A. Koupparis, et al.; The Analyst 111, 1311 (1986) | (6) C.M. Corns; Ann. Clin. Biochem. 24, 591 (1987) | (7) J.I. Monreal, et al.; Rev. Esp. Fisiol. 43, 133 (1987) | (8) E. Hilario, et al.; J. Biochem. Biophys. Methods 21, 197 (1990) | (9) R.M. Liu, et al.; Talanta 40, 511 (1993) | (10) J.K. Choi, et al.; Electrophoresis 23, 4053 (2002) | (11) G.B. Smejkal & H.F. Hoff; Biotechn. 34, 486 (2003) | (12) C.E. Saebel, et al.; Anal. Biochem. 397, 218 (2010)